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Grant Application

PSC Partners Seeking a Cure

Grant Application

Apply for a Research Grant

PSC Partners Seeking a Cure is a 501(c)(3) nonprofit organization whose mission is to provide education and support to PSC patients, families and caregivers and to raise funds to research causes, treatments and cures for primary sclerosing cholangitis. PSC Partners offers grants to conduct research that addresses an important and novel, basic or clinical research question related to PSC and closely associated diseases (such as inflammatory bowel diseases (IBD), ulcerative colitis (UC) or Crohn’s disease) as they relate to PSC. The applicant must be at an academic institution with an interest in pursuing PSC as an indication for treatment. The purpose is to encourage investigators to conduct research in promising new areas with the goal that data generated will lead to federal (NIH) funding. Funding is limited to $30,000 per year for 2 years ($60,000 total). However, focused proposals with smaller budget requests will also be considered. This year’s application deadline was April 1, 2017; the application period is now closed.

PSC Partners Seeking a Cure is particularly interested in funding research projects that have the potential to discover a cure for this disease, and/or identify novel therapies that may significantly delay time to liver transplantation, prevent disease recurrence following liver transplantation, and/or improve the quality of life of those with PSC. PSC Partners understands that much fundamental research is necessary to discover the environmental factors that may trigger this disease in genetically susceptible individuals, and therefore we would like to encourage research proposals aimed at identifying the gene-environment interactions contributing to disease initiation and progression. PSC Partners recognizes that studies with animal models may be appropriate to address these fundamental questions. We are interested in funding research that explores PSC-related diseases (IBD, UC, and Crohn’s disease) in ways that they impact, enable, or perhaps cause PSC. PSC Partners encourages research that will be complementary to the goals and objectives of the International PSC Study Group, including investigation of the functional roles of genes associated with susceptibility to and severity of PSC. Other priority areas for research include the mechanisms of PSC pathogenesis and colorectal and cholangiocarcinoma carcinogenesis as well as strategies for prevention. Applications focused on assessing and improving the quality of life of PSC patients are also encouraged. Proposals that have little relevance to PSC will not be considered for funding. We strongly encourage interdisciplinary collaborations and the sharing of resources as a means of accelerating progress in PSC research. If the proposal includes a specific plan for sharing of results and resources (such as DNA), this will result in a more favorable review.  Applications addressing PSC in children are strongly encouraged.

Application Instructions

No special application forms are needed. One copy of each full application must be submitted electronically in the English language, and in portable document format (.pdf) to: contactus@pscpartners.org. The instructions below should be followed:

1. Face Sheet
Please include the title of the research project, the name and title of the principal investigator (PI), the PI’s mailing address and e-mail address, and the names, titles, and e-mail address of any co-PIs.

2. Budget
The Scientific/Medical Advisory Committee may exercise discretion in the approval of the expenditure of funds, but since these are small research grants, they are primarily intended to support the purchase of consumable research supplies (e.g. glassware, chemicals, enzymes, etc.) to conduct PSC research. Salary support for principal investigators is not allowed, but salary support for technicians will be allowed. Indirect costs (overhead) will not be allowed.

3. Budget Justification
Items to be purchased and salary support should be briefly explained and justified.

4. Project Description
This segment of the proposal should be no longer than 7 pages. Please use the following format:

  1. Project Summary – Approximately 250 words
  2. Specific Aims.
  3. Background and Significance
  4. Preliminary Data (optional)
  5. Research Plan (include materials and methods, collaborative arrangements, interpretation of data, anticipated results, potential problems, and alternative approaches).

5. Bibliography (Literature Cited)

6. Facilities and Equipment

7. Institutional Review Board
If the study includes human subjects, proof of approval by the applicant’s Institutional Review Board must be included, as well as a copy of the approved consent form. Grant applications will be accepted for review if the applicant’s Institutional Review Board document is still pending approval. However, funding would be contingent upon submission of the final approved IRB document.

8. Biographical Sketch of the Applicant (PI)
Submit your biosketch according to the NIH format.

9. List of Current and Pending Support

Incomplete applications will not be considered.  Completed grant applications should be typed, in English, and sent as a .pdf file. Please submit via e-mail to:

Ricky Safer
PSC Partners Seeking a Cure
contactus@pscpartners.org

PSC Partners Seeking a Cure will issue a confirmation email upon receipt of each individual application. The principle investigator will be notified. Please contact us at contactus@pscpartners.org if a confirmation email is not received and we will verify the status of the application.

Application Review

All grant applications will be reviewed by members of the PSC Partners Seeking a Cure Scientific/Medical Advisory Committee. Ad hoc reviewers will be used when appropriate. Renewal applications will be judged in competition with other applications.

The following points will be taken into consideration when the proposals are reviewed:

  1. Is the proposed research relevant to the research mission of PSC Partners Seeking a Cure?
  2. Does the proposal have scientific merit?
  3. Are the hypotheses to be tested based on sound, logical principles, and are the specific aims delineated in the proposal adequate to test the hypotheses?
  4. Are the methods appropriate?
  5. Is the approach innovative?
  6. Will the proposal serve as a foundation to establish a novel line of research that will be competitive for NIH, NSF, VA or other external funding?
  7. Does the proposed research have a high probability of success?
  8. Is the applicant qualified to carry out the proposed study, and are the facilities adequate?
  9. Is the proposal clear and concise? Has the appropriate literature been consulted and cited? Does the proposal give attention to detail?
  10. Does the proposal contain a specific plan for sharing of results and resources (e.g. DNA), and does it entail inter-disciplinary collaboration?
  11. Is the budget appropriate and adequately justified?
  12. Will the proposal impact PSC patient treatment in the short-term?
  13. What are the overall strengths and weaknesses of the proposal?

Notification of funding (or lack thereof) will be made approximately three months after the proposal submission deadline.

Progress Reports

Awardees will be expected to provide a 1- to 2-page annual summary of results obtained with funds provided by PSC Partners Seeking a Cure. This report should include a list of publications and abstracts presented at scientific meetings. We request that all publications resulting from research funds provided by PSC Partners Seeking a Cure should include an acknowledgement of this support.

Review awards we’ve made in the past by clicking here.